Serums containing ingredients like vitamin C, niacinamide, kojic acid, alpha arbutin, or retinoids are effective for treating dark spots. The best choice depends on skin type and sensitivity; start with a lower concentration and gradually increase as tolerated. Patch-testing is recommended before full application.

Serums can significantly fade dark spots with consistent use over time, but complete removal isn't always guaranteed. The effectiveness depends on the severity and age of the dark spots, as well as the serum's ingredients and concentration; professional treatments like lasers may be needed for complete removal in some cases.